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SKU: 0847ATC

1321N1 Human Brain Astrocytoma Glial Cells

Tumor Cell Lines > Brain Cancer Cell Lines

Product Type: Human Brain Cancer Cell Lines

Species: Human

Cell Type: Glial Cells

Source Organ: Brain

$1,249.00
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Cell Name: 1321N1

Human brain astrocytoma. 1321N1 is a human astrocytoma cell line isolated in 1972 as a sub clone of the cell line 1181N1 which in turn was isolated from the parent line U-118 MG (one of a number of cell lines derived from malignant gliomas by J Ponten.).

  • Description
    1321N1 is a human astrocytoma cell line originally derived as a subclone of 1181N1. It was established from a 47-year-old Caucasian male and displays polygonal morphology with adherent, monolayer growth, showing glial characteristics. These cells are low-tumorigenic in nude mice but widely used in neuropharmacological studies. 1321N1 expresses M2, M3, and M5 muscarinic receptors involved in phosphoinositide signaling, forming G-protein-coupled complexes influencing smooth muscle and CNS function. Upon stimulation, they release IP3, trigger intracellular calcium waves, and induce ATP release, facilitating intercellular communication. The line also expresses classic astrocytic markers such as GFAP, vimentin, and S-100 protein. Genetically, 1321N1 is hypodiploid with chromosomal abnormalities and harbors a homozygous TP53 mutation (p.Arg213Gln) and PTEN splice site mutation (c.1026+1G>T). Additionally, mitochondrial DNA mutations disrupt respiratory complexes I and IV, increasing oxidative stress.
  • Product Name
    1321N1
  • Product Type
    Human Brain Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Glial
  • Source Organ
    Brain
  • Disease
    Astrocytoma
  • Product Type
    Human Brain Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    1321N1 cell line is a valuable tool for studying human astrocytoma biology and key signaling pathways. Researchers utilize this cell line as a model system to investigate the toxicity of dust particles generated during molten silicomanganese (SiMn) exposure to air. Additionally, the 1321N1 cell line is employed in studying the influence of thin film morphology on human astrocytoma cell behavior in vitro. It has been instrumental in studying the Caytaxin protein expression and activity, making it an essential tool in diverse research endeavors concerning human astrocytoma and related fields.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 2mM Glutamine + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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