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SKU: 0188ATC

A-673 Human Muscle Ewing Sarcoma Specialized Cells

Tumor Cell Lines > Sarcoma Cell Lines

Product Type: Human Sarcoma Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Muscle

$1,249.00
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Cell Name: A-673

Tissue: muscle Disease: Ewing sarcoma

  • Description
    A-673 is a human Ewing sarcoma cell line originally isolated from the muscle tissue of a 15-year-old female patient. This adherent cell line displays a polygonal to fibroblast-like morphology and proliferates as a monolayer in culture. A-673 harbors a complex karyotype, including multiple marker chromosomes, an extra F chromosome, and the hallmark t(11;22)(q24;q12) translocation, which is characteristic of Ewing Sarcoma. A-673 demonstrates strong tumorigenic and metastatic potential, forming colonies in soft agar and developing metastatic lesions when xenografted into SCID mice models. The cell line exhibits heightened susceptibility to human adenovirus infection and secretes both oncogenic growth factors and growth-inhibitory molecules, providing a balanced model for studying tumor microenvironment interactions.
  • Product Name
    A-673
  • Product Type
    Human Sarcoma Cell Lines
  • Species
    Human
  • Source Organ
    Muscle
  • Disease
    Ewing sarcoma
  • Product Type
    Human Sarcoma Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    A-673 cell line provide a versatile platform for studying the molecular and cellular mechanisms underlying Ewing sarcoma. These cells are extensively used in development of xenograft tumor models, enabling the study of tumor progression, angiogenesis, and metastatic behavior. Additionally, A-673 cells are instrumental in evaluating the efficacy of novel anti-cancer agents, particularly those targeting tumor vasculature or growth pathways. Their dual expression of oncogenic and inhibitory factors makes them ideal for dissecting the balance between tumor stimulation and suppression within the tumor microenvironment, facilitating advancements in targeted therapies for Ewing’s Sarcoma.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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