SKU: 0257ATC

Alpha TC1-9 Mouse Pancreas Islet Cell Adenoma Specialized Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Mouse Pancreas Cancer Cell Lines

Species: Mouse. (C57BL/6J X DBA/2)F2 (Transge

Cell Type: Other / Specialized Cells

Source Organ: Pancreas

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Cell Name: Alpha TC1-9

  • Description
    Alpha TC1-9 is a murine pancreatic alpha-cell model derived from an islet cell adenoma in transgenic mice (C57BL/6 × DBA/2 hybrids), immortalized using the SV40 large T antigen. These cells exhibit epithelial-like morphology and adherent growth properties. Cytogenetic analysis reveals aneuploidy, yet this line retains key alpha-cell functions, including glucagon secretion regulated by extracellular glucose concentrations. Alpha TC1-9 exhibits MHC heterozygosity reflective of its mixed parental background. Unlike its progenitor, Alpha TC1, this subclone does not express insulin or preproinsulin mRNA, making it a specific model for alpha-cell function without beta-cell interference. The cell line serves as a critical tool for studying alpha-cell physiology, chemical toxicity, and transdifferentiation mechanisms.
  • Product Name
    Alpha TC1-9
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Species
    Mouse. (C57BL/6J X DBA/2)F2 (Transge
  • Cell Type
    α Cell
  • Source Organ
    Pancreas
  • Disease
    Islet Cell Adenoma
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Alpha TC1-9 cell line offers a versatile platform for exploring multiple aspects of pancreatic alpha-cell biology. It facilitates detailed investigations of glucagon biosynthesis, biosynthesis, glucose sensing and cytokine responsiveness, contributing to a comprehensive understanding of the intricate regulation of glucose sensing and glucagon secretion. Furthermore, it plays a crucial role in elucidating the impacts of metabolism-disrupting chemicals on pancreatic endocrine function. Importantly, this cell line supports research into the transdifferentiation potential of alpha-cells into beta-cells, thus offering promising avenues for beta-cell regeneration and in diabetes research and therapeutic development.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    2

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