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SKU: 010NTC

ARPE19 Human Eye Epithelial Cells

Non-Tumor Continuous Cell Lines > Eye Cell Lines

Product Type: Human Retinal Pigment Epithelium Cell Line

Species: Human

Cell Type: Epithelial Cells

Source Organ: Eye

$1,249.00
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Cell Name: ARPE19

  • Description
    ARPE-19 is a spontaneously immortalized human retinal pigment epithelial (RPE) cell line established from the normal eye of a 19-year-old male donor. These adherent cells retain key morphological and functional features of native RPE, including polarization, tight junction formation, and epithelial monolayer organization when cultured on laminin-coated membranes under low-serum conditions. ARPE-19 expresses hallmark RPE markers such as CRALBP and RPE-65, indicative of its physiological relevance. The cells exhibit a doubling time of 55–65 hours and support up to 48 population doublings, maintaining viability and consistent gene expression across passages. Compared to iPSC-derived RPE cells, ARPE-19 shows elevated expression of genes related to chromatin regulation, eye development, and muscle contraction networks.
  • Product Name
    ARPE19
  • Product Type
    Human Retinal Pigment Epithelium Cell Line
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Eye
  • Disease
    Normal
  • Product Type
    Human Retinal Pigment Epithelium Cell Line
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    ARPE-19 cells are a widely recognized in vitro model in ophthalmic research, particularly for studying retinal pigment epithelium physiology, ocular drug transport, and retinal disease mechanisms. They are instrumental in modeling age-related macular degeneration (AMD), oxidative stress responses, and RPE-mediated phagocytosis of photoreceptor outer segments. Additionally, ARPE-19 supports transfection and gene expression studies, enabling exploration of pigmentation, retinal metabolism, and barrier function. However, ARPE-19 contains a mixture of mortal and immortal cell populations, and its gene expression profile differs from native RPE cells, therefore, careful experimental validation is advised when modeling retinal pathophysiology or evaluating therapeutic interventions.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM/F12 + 10% FBS
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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