SKU: 0876ATC

bEnd.3 Mouse Brain Endothelioma Endothelial Cells

Tumor Cell Lines > Brain Cancer Cell Lines

Product Type: Mouse Brain Cancer Cell Lines

Species: Mouse

Cell Type: Endothelial Cells

Source Organ: Brain

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Ship on dry ice.

Cell Name: bEnd.3

The cells were transformed by infection with the NTKmT retrovirus vector that expresses polyomavirus middle T antigen. The endothelial nature of these cells was confirmed by the observed expression of von Willebrand factor and uptake of fluorescently la.

  • Description
    bEnd.3 is a mouse endothelial cell line originally derived from the cerebral cortex of a 6-week-old BALB/c mouse with endothelioma. These cells exhibit typical endothelial morphology and adherent growth properties. bEnd.3 cells can be induced by cytokines and lipopolysaccharide (LPS) to express molecules such as Peyer’s junction high endothelial cell receptor, mucosal vascular settlement factor (MAdCAM-1), and endothelial cell selectins. They are positive for various endothelial-specific proteins, including PECAM-1, Endoglin, MECA-32, and Flk-1, as confirmed by Flow Cytometry (FACS) analysis.
  • Product Name
    bEnd.3
  • Product Type
    Mouse Brain Cancer Cell Lines
  • Species
    Mouse
  • Cell Type
    Endothelial
  • Source Organ
    Brain
  • Disease
    Endothelioma
  • Product Type
    Mouse Brain Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The bEnd.3 cell line is a valuable model for both vascular biology and neuroscience research. It plays a crucial role in understanding diseases linked to the lymphatic and vascular systems, including endothelioma. Notably, these cells are particularly widely used to investigate blood-brain barrier (BBB) disruption and to assess potential therapeutic interventions targeting neurological and vascular pathologies. Additionally, their adaptability to 3D cell culture models allow researchers to simulate complex physiological conditions, enhancing the relevance of in vitro models for disease mechanism studies and drug development.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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