SKU: 0291ATC

Beta-TC-6 Mouse Insulinoma Epithelial Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Mouse Pancreas Cancer Cell Lines

Species: Mouse

Cell Type: Epithelial Cells

Source Organ: Other

Inquire about this product

Delivery and Shipping

Ship on dry ice.

Cell Name: Beta-TC-6

The cell line was derived from a pancreatic tumor (RIoma) arising in a transgenic mouse. The mouse carried the pseudogene construct composed of the SV40 early region controlled by the rat RI II gene promotor. The cells contain abundant insuli.

  • Description
    Beta-TC-6 is a murine pancreatic β-cell line derived from an insulinoma-formed in a transgenic mouse carrying a rat insulin II promoter-driven SV40 early gene pseudogene construct. These cells exhibit epithelial-like morphology and grow in adherent, island-like clusters. Beta-TC-6 retain key functional β-cell characteristics, including glucose-responsive insulin secretion and predominant insulin expression by Beta-TC-6 cells, alongside minor expression of glucagon and somatostatin. They express PDX1, a critical transcription factor for β-cell identity and insulin gene regulation. They harbor the SV40 large T antigen, contributing to their immortalized tumorigenic properties.
  • Product Name
    Beta-TC-6
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Species
    Mouse
  • Cell Type
    Epithelial
  • Disease
    Insulinoma
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Beta-TC-6 cell line plays a pivotal role for studying pancreatic β-cell biology, particularly within the domains of diabetes mellitus and glucose metabolism. Its glucose-responsiveness and insulin-secretory capacity make it an invaluable tool for delving into the molecular mechanisms of insulin regulation, β-cell differentiation, and dysfunction in diabetic states. Beta-T-6 is widely used in screening anti-diabetic compounds, investigating islet cell gene expression, and evaluating the impact of genetic or pharmacological modulation on insulin pathways. Consequently, holds promise for studies in β-cell regeneration, islet transplantation, and novel diabetic therapeutic interventions.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    Product inquiry

    Tell us what you need and our team will get back to you with pricing and availability.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you