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SKU: 0291ATC

Beta-TC-6 Mouse Insulinoma Epithelial Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Mouse Pancreas Cancer Cell Lines

Species: Mouse

Cell Type: Epithelial Cells

Source Organ: Other

$1,249.00
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Cell Name: Beta-TC-6

The cell line was derived from a pancreatic tumor (RIoma) arising in a transgenic mouse. The mouse carried the pseudogene construct composed of the SV40 early region controlled by the rat RI II gene promotor. The cells contain abundant insuli.

  • Description
    Beta-TC-6 is a murine pancreatic β-cell line derived from an insulinoma-formed in a transgenic mouse carrying a rat insulin II promoter-driven SV40 early gene pseudogene construct. These cells exhibit epithelial-like morphology and grow in adherent, island-like clusters. Beta-TC-6 retain key functional β-cell characteristics, including glucose-responsive insulin secretion and predominant insulin expression by Beta-TC-6 cells, alongside minor expression of glucagon and somatostatin. They express PDX1, a critical transcription factor for β-cell identity and insulin gene regulation. They harbor the SV40 large T antigen, contributing to their immortalized tumorigenic properties.
  • Product Name
    Beta-TC-6
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Species
    Mouse
  • Cell Type
    Epithelial
  • Disease
    Insulinoma
  • Product Type
    Mouse Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Beta-TC-6 cell line plays a pivotal role for studying pancreatic β-cell biology, particularly within the domains of diabetes mellitus and glucose metabolism. Its glucose-responsiveness and insulin-secretory capacity make it an invaluable tool for delving into the molecular mechanisms of insulin regulation, β-cell differentiation, and dysfunction in diabetic states. Beta-T-6 is widely used in screening anti-diabetic compounds, investigating islet cell gene expression, and evaluating the impact of genetic or pharmacological modulation on insulin pathways. Consequently, holds promise for studies in β-cell regeneration, islet transplantation, and novel diabetic therapeutic interventions.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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