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SKU: 0035APC

Bovine Rumen Intestinal Epithelial Cells

Primary Cells > Intestine & Gastrointestinal Cells

Product Type: Rumen Intestinal Cells

Species: Bovine

Cell Type: Epithelial Cells

Source Organ: Intestine

$1,249.00
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Cell Name: Bovine Rumen Intestinal Epithelial Cells

  • Description
    Primary bovine ruminal epithelial cells (BRECs) are isolated from calf rumen tissue and cultured to retain squamous morphology, tight junctions, desmosomes, and key SCFA transporters (MCT1/MCT4). They actively absorb and metabolize volatile fatty acids, produce ketone bodies, and maintain barrier integrity essential for nutrient uptake and defense. BRECs respond physiologically to insulin, IGF‑1, butyrate, TGF‑β, and pH shifts by modulating proliferation, differentiation, apoptosis, and inflammatory cytokine signaling (e.g., IL‑1β, TNF‑α). These features render BRECs a robust in vitro model for rumen development, acidosis, epithelial transport, immune responses, and dietary or drug effects.
  • Product Name
    Bovine Rumen Intestinal Epithelial Cells
  • Product Type
    Rumen Intestinal Cells
  • Species
    Bovine
  • Cell Type
    Epithelial Cell
  • Source Organ
    Rumen Intestine
  • Disease
    Normal
  • Product Type
    Rumen Intestinal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Bovine Rumen Intestinal Epithelial Cells are utilized to study rumen epithelial functions including nutrient and SCFA uptake (e.g., MCT‑mediated absorption) and ketogenesis under butyrate and insulin/IGF‑1 stimulation. They model barrier integrity and pH stress responses, particularly in acidosis scenarios, by assessing tight junctions, apoptosis pathways, and transcriptomic changes. They also serve as a platform for inflammation research, as SCFA exposure triggers GPR41-mediated cytokine (IL‑1β, TNF‑α) and chemokine expression—offering insights into innate immunity regulation in the rumen epithelium.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Bovine Rumen Intestinal Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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