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SKU: 0868ATC

C6 Rat Brain Malignant Glioma Fibroblasts Cell Line

Tumor Cell Lines > Brain Cancer Cell Lines

Product Type: Rat Nerve Cell Lines

Species: Rat

Cell Type: Fibroblasts

Source Organ: Brain

$1,249.00
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Cell Name: C6

S-100 production increases ten fold as cells grow from low density to confluencyTumorigenecity: Isoenzyme: Histopathology: gliomaSubculture: Split ratio: Media change: Reverse transcritase: negativeProductionS-100 protein; Produce glyceralphosphate dehydrogenase in response to glucocorticoids; Somatotropin.

  • Description
    C6 is a rat glioma cell line originally derived from an N-nitrosomethylurea-induced brain tumor in an adult male Wistar-Furth rat. These cells exhibit fibroblast-like morphology and adherent culture properties, with a doubling time of 25-30 hours. Cytogenetic analysis indicates a diploid male karyotype. They overexpress glioma-associated markers such as S-100 and glial fibrillary acidic protein (GFAP), and they activate human tumor-relevant pathways, including PDGFβ and EGFR, mimicking key features of human gliomas. They display tumorigenicity in immunocompromised mice under subcutaneous inoculation with demonstrated metastatic potential to distant organs including lungs. C6 cells are also susceptible to neurotropic viruses, including lymphocytic choriomeningitis virus (LCMV), herpes simplex (HSV), and vaccinia virus. Its responsiveness to extracellular matrix (ECM) components through upregulated Ras pathway activity enhances its utility in studying tumor microenvironment interactions.
  • Product Name
    C6
  • Product Type
    Rat Nerve Cell Lines
  • Species
    Rat
  • Cell Type
    Fibroblast
  • Source Organ
    Brain
  • Disease
    Malignant Glioma
  • Product Type
    Rat Nerve Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The C6 rat glioma cell line serves as a capable model for studying the biology of glioblastoma multiforme (GBM) and related high-grade gliomas. It is widely employed in neuro-oncology research, particularly in drug discovery. Its tumorigenicity enables the creation of orthotopic and subcutaneous xenograft models, facilitating in vivo assessment of drug efficacy, resistance mechanisms, and invasion patterns of therapeutic agents. Researchers use C6’s unique PDGFβ/EGFR pathway activation along with S-100/GFAP overexpression to investigate glioma-stromal interactions, tumor invasiveness, and tumor-induced angiogenesis. Furthermore, its viral susceptibility profile facilitates studies on oncolytic virotherapy and blood-brain barrier dynamics.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    F12K + 15% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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