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SKU: 0012ATC

Ca Ski Human Cervix Epidermoid Cancer Epithelial Cells

Tumor Cell Lines > Uterine Cancer Cell Lines

Product Type: Human Uterine Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Cervix

$1,249.00
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Cell Name: Ca Ski

Ca Ski Cell Line is from human; Sex: F; Tissue: uterine cervix; Morphology: epithelial-like; Profile: Human epidermoid cervical cancer cell line.

  • Description
    Ca Ski is a human epidermoid cervical carcinoma cell line derived from metastatic lesions in the small bowel mesentery of a 40-year-old Caucasian female patient. This cell line exhibits an epithelial-like, polygonal morphology with adherent growth properties. Its doubling time is approximately 72 hours. Ca Ski harbors complex karyotypic abnormalities, including recurrent chromosomal translocations [der(5)t(5;8)(p13;q23)] and deletions in the 5p11/5q11 regions. A defining feature of this cell line is the integration of high-copy human papillomavirus type 16 (HPV-16) DNA and sequences related to HPV-18. It expresses the β-subunit human chorionic gonadotropin (β-hCG), tumor-associated antigens and glucose-6-phosphate dehydrogenase type B (G6PD-B). Ca Ski demonstrates tumorigenic potential in xenograft models and has been widely used to study cancer metastasis mechanisms, particularly in migration and invasion assays.
  • Product Name
    Ca Ski
  • Product Type
    Human Uterine Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Cervix
  • Disease
    Epidermoid Cancer
  • Product Type
    Human Uterine Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Ca Ski presents a multifaceted utility in biomedical research. In cancer research, Ca Ski cells are particularly relevant for investigating cervical cancer pathogenesis, progression, and potential therapeutic interventions. Moreover, the presence of integrated HPV DNA makes it especially useful for exploring the molecular mechanisms underlying HPV infection and its role in cervical tumor development, shedding light on crucial aspects of these sexually transmitted diseases. Additionally, Ca Ski cells are utilized in assays investigating cell invasion, migration, and metastasis, contributing to a broader understanding of cancer biology and therapeutic targeting.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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