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SKU: 0875ATC

Caco-2 Human Colon Colon Adenocarcinoma Epithelial Cells

Tumor Cell Lines > Colon Cancer Cell Lines

Product Type: Human Colon Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Intestine

$1,249.00
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Cell Name: Caco-2

This line was isolated from a primary colonic tumor. Upon reaching confluence, the cells express characteristics of enterocytic differentiation. Caco-2 cells express retinoic acid binding protein I and retinol binding protein II, and are keratin positive.

  • Description
    Caco-2 is a human epithelial tumor cell line derived from a primary colorectal adenocarcinoma of a 72-year-old Caucasian male patient. Originating from the colon, Caco-2 cells grow as an adherent monolayer with cobblestone-like morphology and differentiate into enterocyte-like cells when cultured to confluence. They develop tight junctions and apical microvilli, forming a brush border like intestinal epithelium. The cells express retinoic acid binding protein I, retinol binding protein II, and keratin, showing increased alkaline phosphatase activity during differentiation. Although derived from cancer tissue, Caco-2 cells show low tumorigenicity and are considered non-tumorigenic in immunodeficient mice. Free of major viral contaminants, they are classified as BSL-1. Caco-2 cells are ideal for studying drug absorption, nutrient transport, and intestinal permeability due to their ability to form high-resistance polarized monolayers.
  • Product Name
    Caco-2
  • Product Type
    Human Colon Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Colon
  • Disease
    Colonic Adenocarcinoma
  • Product Type
    Human Colon Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Caco-2 cells are widely used as a intestinal epithelial barrier model. One significant is their use in forecasting intestinal drug permeability. Caco-2 monolayers are aligned with in vivo transport pathways, evaluating their similarities. Additionally, Caco-2 monolayers serve as a benchmark for absorption prediction models of drug absorption. Overall, Caco-2 monolayers are valuable for identifying drugs with potential absorption issues and selecting optimal drug candidates with desirable passive permeability traits during drug discovery programs.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    EMEM + 20% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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