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SKU: 099BIC

Canine Bone Marrow Dendritic Cells

Blood and Immune Cells & Products > Bone Marrow Cells

Product Type: Canine Primary Cells

Species: Canine

Cell Type: Immune Cells

Source Organ: Bone Marrow

$1,249.00
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Cell Name: Canine Bone Marrow Dendritic Cells

  • Description
    Canine Bone Marrow Dendritic Cells are primary immune cells isolated from the femurs and tibias of healthy male and female beagle dogs. In vitro, they are non-adherent and short-lived. They are derived from hematopoietic progenitors and differentiated using GM-CSF or Flt3L. Cells express CD4, CD8, CD1c, CD11b, CD11c, and CD14, detected by flow cytometry or immunofluorescence. LPS stimulation induces MHC-II and co-stimulatory molecule expression. Karyotype analysis has not been reported. They are non-tumorigenic and non-metastatic, free of Mycoplasma, bacteria, fungi, yeast, and tested negative for canine-specific viruses like CDV and CAV. These cells are ideal for veterinary immunology and translational antigen-presentation studies under BSL-2 conditions.
  • Product Name
    Canine Bone Marrow Dendritic Cells
  • Product Type
    Canine Primary Cells
  • Species
    Canine
  • Cell Type
    DC Cell
  • Source Organ
    Bone Marrow
  • Disease
    Normal
  • Product Type
    Canine Primary Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Canine Bone Marrow Dendritic Cells (caDC) are valuable for investigating immune-mediated diseases, graft rejections, and cancers in canine models for immune-mediated diseases, graft rejections, and cancers. Characterizing caDC subsets and their role in inflammation and immune responses is crucial for advancing veterinary immunology.Furthermore, they show promise as a novel immunotherapy for canine cancers, as they can be induced to stimulate tumor-specific CD8 T cells, opening avenues for innovative and targeted therapeutic approaches in veterinary oncology.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Canine Bone Marrow Dendritic Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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