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SKU: 0032APC

Canine Epididymal Epithelial Cells

Primary Cells > Reproductive System Cells

Product Type: Epididymal Cells

Species: Canine

Cell Type: Epithelial Cells

Source Organ: Epididymis

$1,249.00
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Cell Name: Canine Epididymal Epithelial Cells

  • Description
    Canine Epididymal Epithelial Cells (CEECs) are primary cells isolated from the caput region of the canine epididymis, which retain a polarized pseudostratified morphology. They express tight junction proteins, including claudin‑1 and occludin, which are essential for maintaining the epithelial barrier. These cells are also involved in nutrient transport, as evidenced by the expression of monocarboxylate transporter 1 (MCT1). CEECs play a critical role in mechanotransduction, responding to fluid shear stress by activating primary cilia, which initiate intracellular calcium signaling and cytoskeletal remodeling. Moreover, they exhibit innate immune responses, activating Toll‑like receptor 3 (TLR3) and secreting proinflammatory cytokines, such as tumor necrosis factor‑α (TNF‑α) and monocyte chemoattractant protein‑1 (MCP‑1), upon exposure to viral mimics.
  • Product Name
    Canine Epididymal Epithelial Cells
  • Product Type
    Epididymal Cells
  • Species
    Canine
  • Cell Type
    Epithelial Cell
  • Source Organ
    Epididymis
  • Disease
    Normal
  • Product Type
    Epididymal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Canine Epididymal Epithelial Cells (CEECs) are utilized to study epithelial barrier function, specifically nutrient uptake through MCT1-dependent pathways. They are also used in mechanotransduction research to examine primary cilia signaling and cytoskeletal changes under shear stress. CEECs provide an effective model for studying innate immune responses, especially TLR3 activation and subsequent cytokine production. Additionally, these cells support investigations into sperm–epithelial interactions, making them a valuable tool for reproductive and fertility research.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Canine Epididymal Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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