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SKU: 0815ATC

COLO-800 Human Skin Cutaneous Melanoma Fibroblasts Cell Line

Tumor Cell Lines > Melanoma Cell Lines

Product Type: Human Melanoma Cell Lines

Species: Human

Cell Type: Fibroblasts

Source Organ: Skin

$1,249.00
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Cell Name: COLO-800

Human melanoma. Derived from a subcutaneous nodule of a tumour from a 14-year-old male. Cells display remarkable blebbing. COLO 800 and COLO 794 were both derived from the same 14 year old male This has been confirmed by STR profiling.

  • Description
    COLO-800 is a human cutaneous melanoma cell line that was originally isolated from a subcutaneous nodule of a 14-year-old male patient with melanoma. COLO-800 exhibits mainly epithelial-like morphology with few look like fibroblasts or neurons and adherent culture properties. A basic characteristic of these cells is the ability to produce melanin. The pro-oxidative effect of melanin leads to increased levels of oxygen free radicals within the cells, which in turn damages the DNA of melanocytes. These mutations result in the overactivation of various cell signaling pathways, such as the MAPK pathway, leading to uncontrolled proliferation, dedifferentiation, and immortalization of specific cell types.
  • Product Name
    COLO-800
  • Product Type
    Human Melanoma Cell Lines
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Skin
  • Disease
    Cutaneous Melanoma
  • Product Type
    Human Melanoma Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The COLO-800 cell line is used as a tumor model to simulate melanoma, making it critical for understanding the molecular mechanisms underlying melanoma tumorigenicity and treatment resistance. Research on the genetic pathways of this cell line may help identify genes related to melanoma development and provide a theoretical basis for diagnosing and treating hereditary melanoma.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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