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SKU: 0149ATC

Colon-26 Mouse Specialized Cells

Tumor Cell Lines > Colon Cancer Cell Lines

Product Type: Mouse Colon Cancer Cell Lines

Species: Mouse

Cell Type: Other / Specialized Cells

Source Organ: Other

$1,249.00
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Cell Name: Colon-26

Established ‘in vitro’ from the colon-26 tumor of female mice. This tumor was induced in Balb/c mice by single rectal application of N-Nitroso-N-Methylurethan (NMU).The species was confirmed by Real-Time PCR.

  • Product Name
    Colon-26
  • Product Type
    Mouse Colon Cancer Cell Lines
  • Species
    Mouse
  • Product Type
    Mouse Colon Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Colon-26 cells are used to establish a cachectic mouse model for studying cancer cachexia, which is a syndrome of progressive loss of skeletal muscle mass and adipose tissue, causing weight loss and weakness. After inoculation of colon-26 cells, the following syndromes were observed in the transplanted mice: the sustaining and extensive weight loss as tumor growth, hypoglycemia, hypercorticism, and disorders of hepatic functions. With the growth of colon-26 tumor, the skeletal muscle and adipose tissues were both progressively lost, and the muscle cross-sectional area and muscle strength were reduced. Colon-26-induced muscle depletion may involve activation of skeletal muscle proteolytic systems.The cytokine IL-6 is essential but not entirely sufficient for causing cachexia. Hence, anti-IL-6 antibody can be considered as an effective way to prevent the weight loss induced by cachexia. Otherwise, colon-26 cell line can be used for metastasis studies. The injection of colon-26 cell line into the spleen of wild-type mice induced the expression of tumor necrosis factor alpha (TNF-alpha) and the formation of subsequent liver metastasis, potentially mediated by TNF receptor p55 signaling..
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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