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SKU: 0161ATC

COV434 Human Ovary Ovarian Small Cell Cancer Specialized Cells

Tumor Cell Lines > Ovarian Cancer Cell Lines

Product Type: Human Ovarian Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Ovary

$1,249.00
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Cell Name: COV434

Human ovarian granulosa tumour. Human ovarian granulosa tumour cell line established from a solid primary tumour.

  • Description
    The COV434 cell line is a human ovarian cancer cell line established from a solid primary ovarian tumor in a 26- to 27-year-old female patient. COV434 cells show epithelial-like morphology, polygonal shape, and adherent growth in DMEM with 10% FBS at 37°C, 5% CO₂. They possess a near-diploid karyotype with low chromosomal complexity and show loss of SMARCA4 and SMARCA2, while SMARCB1/INI1 remains intact. These cells express FSH receptor, aromatase, AE1/AE3, and Toll-like receptors but lack LH receptor. They constitutively secrete IL-8, supporting immune-oncology research. In vivo, COV434 is tumorigenic, forming tumors with elevated serum calcium—a hallmark of SCCOHT—though migratory and invasive potential is limited.
  • Product Name
    COV434
  • Product Type
    Human Ovarian Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Ovary
  • Disease
    Ovarian Small Cell Cancer
  • Product Type
    Human Ovarian Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The COV434 cell line has multiple important s in ovarian research. Firstly, it can serve as an in vitro model to assess therapeutic interventions on the growth and survival of ovarian cancer cells. Researchers can use COV434 cells to evaluate anti-proliferative treatment efficacy. Additionally, studying COV434 cells enables the investigation of signaling pathways associated with ovarian cancer cell proliferation, potentially uncovering new therapeutic targets. Furthermore, COV434 cells express Toll-like receptors (TLRs) and constitutively secrete IL-8, supporting their use in immunological studies. Their ability to mount an inflammatory response at the transcriptional level upon exposure to pathogen-associated molecular patterns (PAMPs) highlights their potential as the valuable material for studying immune responses.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 2mM Glutamine + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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