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SKU: 1395APC

Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis

Primary Cells > Lung & Airway Cells

Product Type: Pulmonary Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Lung

$1,249.00
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Cell Name: Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis

  • Description
    Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis are derived from the lung tissue of patients with idiopathic pulmonary fibrosis (IPF).These fibroblasts are human in origin, straight from the diseased lung tissue of IPF patients. These cells are long spindle-shaped or star-shaped, with typical fibroblast morphology, and the cells are connected to each other by extracellular matrix. They proliferate in an anchorage-dependent manner.Their karyotype is generally normal but can sometimes show instability due to disease progression. They show abnormal expression of fibrotic markers like alpha-smooth muscle actin (α-SMA) and fibronectin, detectable by immunostaining or PCR.In the pathological process of IPF, lung fibroblasts play a pivotal role by proliferating abnormally and secreting excessive amounts of extracellular matrix components, such as collagen and elastin, which ultimately lead to lung tissue fibrosis.
  • Product Name
    Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis
  • Product Type
    Pulmonary Cells
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Lung
  • Disease
    Idiopathic Pulmonary Fibrosis
  • Product Type
    Pulmonary Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis can be utilized to screen anti-fibrotic compounds or evaluate the efficacy and mechanisms of existing drugs, such as nintedanib or pirfenidone. Furthermore, comparative studies between IPF fibroblasts and healthy lung fibroblasts may help identify disease-specific biomarkers and uncover novel therapeutic targets.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis Medium Kit
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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