Free delivery over $100 Learn more

30 days return period Learn more
SKU: 0800ATC

DMS 454 Human Lung Small Cell Lung Cancer Specialized Cells

Tumor Cell Lines > Lung Cancer Cell Lines

Product Type: Human Lung Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Lung

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: DMS 454

Human Caucasian lung, small cell carcinoma. The small cell carcinoma DMS 454 was isolated in 1981 from lung tissue of a male patient at time of autopsy. The cells contain dense-core vesicles and secrete calcitonin.

  • Description
    DMS-454 is a human small cell lung carcinoma (SCLC) cell line established from the lung tissue of a Caucasian male patient during autopsy. It displays polygonal morphology with adherent growth characteristics and contains dense-core vesicles, secreting calcitonin, indicating neuroendocrine features common to SCLC. The cells can be cultured in Waymouth’s MB 752/1 medium supplemented with 2mM glutamine and 10% fetal bovine serum (FBS), or alternatively in RPMI 1640 with 10% FBS [1]. Routine subculture involves digestion with 0.25% trypsin or trypsin/EDTA and a 1:3 split ratio when cultures reach sub-confluence. Cytogenetic analysis has not been extensively reported, and specific gene mutations remain undefined. However, DMS-454 shares key biological behaviors with other SCLC lines, including likely tumorigenicity and high metastatic potential based on the aggressive nature of its tumor origin. It is suitable for studies on neuroendocrine tumor biology and calcitonin-secreting carcinomas.
  • Product Name
    DMS 454
  • Product Type
    Human Lung Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Lung
  • Disease
    Small Cell Lung Cancer
  • Product Type
    Human Lung Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    DMS-454 is a valuable model for studying small-cell lung cancer and developing new therapies for these patients. For example, the utilization of DMS-454 provides an opportunity to identify the tumor markers specific to small cell lung cancer (SCLC) in the initial stage. Once these markers are identified, the next step involves assessing the effectiveness of antibodies targeting these markers within the context of CAR-T cell therapy. This approach aims to determine whether the antibodies can effectively engage the markers and initiate the desired immune response to eliminate cancer cells.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    Waymouth’s MB 752/1 + 2mM Glutamine + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you