SKU: 0553ATC

EL4.NOB-1 Mouse Blood Lymphoma Lymphoblasts Cell Line

Tumor Cell Lines > Lymphoma Cell Lines

Product Type: Mouse Lymphoma Cell Lines

Species: Mouse

Cell Type: Lymphoblasts

Source Organ: Blood

Delivery and Shipping

Ship on dry ice.

Cell Name: EL4.NOB-1

Mouse C57BL/6N ascites lymphoma lymphoblast. Derived from EL4.BU.OU6. The cells were selected for a high level of IL-1 receptors.

Description

EL4.NOB-1 is a murine lymphoma cell line that was originally isolated from a specific strain of C57BL/6N mice. EL4.NOB-1 exhibits lymphoblast-like morphology and suspension culture properties. This cell line shows elevated expression of the IL-1 receptor and is resistant to TGF-β-induced growth arrest. EL4.NOB-1 also retains sensitivity to both autocrine stimulation and IL-1-induced inhibition of IL-2 production.
Product Name

EL4.NOB-1
Product Type

Mouse Lymphoma Cell Lines
Species

Mouse
Cell Type

Lymphoblast
Source Organ

Blood
Disease

Lymphoma
Growth Conditions

37 °C, 5% CO2
Application

EL4.NOB-1 enables immunology research focused on IL-1 receptor signaling pathways and immune modulation. It models cytokine production through IL-1-induced IL-2 secretion, supporting pharmacological assays using enzyme inhibitors targeting PKC, PKA, MAPK, PLA2, PI-PLC, and PC-PLC. The cell line facilitates cellular growth, autoinduction, and TGF-β resistance studies while investigating IL-1-induced IL-2 suppression. Additionally, it advances signaling pathway analysis of IL-1 receptor activation and molecular biology research characterizing immune signaling genes and proteins.
Size/Quantity

1 vial
Recommended Medium And Supplement

RPMI 1640 + 2mM Glutamine + 10% FBS
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

1

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