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SKU: 0167ATC

EoL-1 cell Human

Tumor Cell Lines > Leukemia Cell Lines

Product Type: Human Leukemia Cell Lines

Species: Human

Cell Type: Lymphoblasts

Source Organ: Blood

$1,249.00
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Cell Name: EoL-1 cell

Cancer; Lifespan: infinite. Eosinophilic leukemia. Differenciate by n-butylate treatment.

  • Description
    EoL-1 is a human acute myeloid leukemia (AML) cell line derived from the peripheral blood of a 33-year-old male patient diagnosed with eosinophilic AML. This cell line exhibits myeloblast-like morphology and grow in suspension culture, with a doubling time of approximately 60 hours under standard conditions. Karyotypic analysis reveals a characteristic KMT2A (MLL) partial tandem duplication, a hallmark genetic alteration in specific AML subtypes. EoL-1 cells express eosinophilic lineage surface markers, including CD11b, CD13, and CD33, and exhibit interleukin-5 (IL-5) sensitivity, enabling their utility in studying eosinophil differentiation pathways .This cell line shows susceptibility to HIV-1 infection, further broadening their utility in modeling host-pathogen interactions. EoL-1 is tumorigenic and serves as a critical model for investigating AML pathophysiology, hematopoietic development, and drug screening.
  • Product Name
    EoL-1 cell
  • Product Type
    Human Leukemia Cell Lines
  • Species
    Human
  • Cell Type
    Lymphoblast
  • Source Organ
    Blood
  • Product Type
    Human Leukemia Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    EoL-1 serves as a valuable model in hematological malignancy research, especially in studies focusing on eosinophilic acute myeloid leukemia (AML) and KMT2A-rearranged leukemias. Its IL-5 responsiveness and eosinophilic marker expression allow for in-depth analysis of eosinophil lineage commitment and differentiation mechanisms. This cell line is also instrumental in evaluating chemotherapeutic agents targeting leukemic blasts or eosinophil differentiation pathways, enabling high-throughput drug efficacy and cytotoxicity screening. Additionally, EoL-1 provides a robust in vitro for exploring virus-host interactions, offering insights into the interplay between hematopoietic malignancies and viral pathogenesis.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    2

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