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SKU: 001NTC

FRTL-5 Rat Specialized Cells

Non-Tumor Continuous Cell Lines > Endocrine Cell Lines

Product Type: Rat Thyroid Cell Lines

Species: Rattus Norvegicus

Cell Type: Other / Specialized Cells

Source Organ: Thyroid

$1,249.00
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Cell Name: FRTL-5

Rat thyroid. This thyroid cell line has been established from normal thyroid glands from 5 to 6-week-old Fischer rats. FRTL-5 is a clonal line of the continuously cultured FRTL cells derived by successive clonal isolation. The cells are characterised by.

  • Description
    FRTL-5 is a thyroid epithelial cell line derived from the normal thyroid gland of a 5- to 6-week-old Fischer rat. Unlike typical thyroid follicular cells, FRTL-5 grows in adherent clusters with a distinctive three-dimensional architecture featuring, characterized by raised central aggregates. Their proliferation is strictly thyroid-stimulating hormone (TSH)-dependent, with a doubling time of 36 ± 6 hours. Karyotype analyses indicate diploid characteristics, typically ranging from 37 to 40 chromosomes. FRTL-5 cells are non-tumorigenic in vivo. This cell line serves as a unique model for studying thyroid hormone synthesis and regulatory pathways, reflecting physiological behaviors absent in cancerous counterparts.
  • Product Name
    FRTL-5
  • Product Type
    Rat Thyroid Cell Lines
  • Species
    Rattus Norvegicus
  • Product Type
    Rat Thyroid Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The FRTL-5 is a robust and widely used model for exploring thyroid physiology and endocrine regulation. It enables in-depth investigation into TSH-regulated processes, including iodide uptake, thyroglobulin synthesis, and sodium-iodide symporter (NIS) activity. FRTL-5 is also used to study the molecular mechanisms of autoimmune thyroid diseases, thyroid hormone metabolism, and the effects of endocrine-disrupting chemicals on thyroid homeostasis. Its non-malignant phenotype and hormone-dependent growth make it particularly suitable for screening thyroid-targeted therapeutics and for modeling conditions such as hypothyroidism and iodine deficiency.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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