SKU: 001NTC

FRTL-5 Rat Specialized Cells

Non-Tumor Continuous Cell Lines > Endocrine Cell Lines

Product Type: Rat Thyroid Cell Lines

Species: Rattus Norvegicus

Cell Type: Other / Specialized Cells

Source Organ: Thyroid

Inquire about this product

Delivery and Shipping

Ship on dry ice.

Cell Name: FRTL-5

Rat thyroid. This thyroid cell line has been established from normal thyroid glands from 5 to 6-week-old Fischer rats. FRTL-5 is a clonal line of the continuously cultured FRTL cells derived by successive clonal isolation. The cells are characterised by.

  • Description
    FRTL-5 is a thyroid epithelial cell line derived from the normal thyroid gland of a 5- to 6-week-old Fischer rat. Unlike typical thyroid follicular cells, FRTL-5 grows in adherent clusters with a distinctive three-dimensional architecture featuring, characterized by raised central aggregates. Their proliferation is strictly thyroid-stimulating hormone (TSH)-dependent, with a doubling time of 36 ± 6 hours. Karyotype analyses indicate diploid characteristics, typically ranging from 37 to 40 chromosomes. FRTL-5 cells are non-tumorigenic in vivo. This cell line serves as a unique model for studying thyroid hormone synthesis and regulatory pathways, reflecting physiological behaviors absent in cancerous counterparts.
  • Product Name
    FRTL-5
  • Product Type
    Rat Thyroid Cell Lines
  • Species
    Rattus Norvegicus
  • Product Type
    Rat Thyroid Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The FRTL-5 is a robust and widely used model for exploring thyroid physiology and endocrine regulation. It enables in-depth investigation into TSH-regulated processes, including iodide uptake, thyroglobulin synthesis, and sodium-iodide symporter (NIS) activity. FRTL-5 is also used to study the molecular mechanisms of autoimmune thyroid diseases, thyroid hormone metabolism, and the effects of endocrine-disrupting chemicals on thyroid homeostasis. Its non-malignant phenotype and hormone-dependent growth make it particularly suitable for screening thyroid-targeted therapeutics and for modeling conditions such as hypothyroidism and iodine deficiency.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    Product inquiry

    Tell us what you need and our team will get back to you with pricing and availability.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you