SKU: 0111ATC

H441 Human Lung Adenocarcinoma Epithelial Cells

Tumor Cell Lines > Lung Cancer Cell Lines

Product Type: Human Lung Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Lung

Delivery and Shipping

Ship on dry ice.

Cell Name: H441

The H441 cell line was derived in 1982 from the pericardial fluid of a patient with papillary adenocarcinoma of the lung.

Description

H441 (NCI-H441) is a human lung papillary adenocarcinoma cell line that was originally isolated in 1982 from the pleural effusion of a male patient with papillary adenocarcinoma of the lung. H441 exhibits epithelial-like morphology and primarily grows as an adherent monolayer. This cell line is hyperdiploid, with a modal chromosome number of 52, though variations from 44 to 59 chromosomes. H441 harbors a KRAS mutation (p.G12V; c.35G>T).
Product Name

H441
Product Type

Human Lung Cancer Cell Lines
Species

Human
Cell Type

Epithelial
Source Organ

Lung
Disease

Papillary Adenocarcinoma
Product Type

Human Lung Cancer Cell Lines
Growth Conditions

37 °C, 5% CO2
Application

The H441 cell line serves as a versatile tool in multiple research fields. In the study of human lung adenocarcinoma, it helps elucidate alterations in intermediate filament protein expression. As a type II pneumocyte cell line in alveolar models, it enables the examination of oxidative stress and pro-inflammatory responses triggered by heated tobacco products. Moreover, it is widely used in transfection experiments to express pulmonary surfactant protein SP-B, contributing to a better understanding of pulmonary physiology and disease.
Size/Quantity

1 vial
Recommended Medium And Supplement

RPMI 1640 + 10% FBS
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

1

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