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SKU: 0039ATC

HeLa S3 Human Cervix Cervical Cancer Epithelial Cells

Tumor Cell Lines > Uterine Cancer Cell Lines

Product Type: Human Uterine Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Cervix

$1,249.00
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Cell Name: HeLa S3

HeLa S3 is a clonal derivative of the parent HeLa line. S3 was cloned in 1955 by T.T. Puck, P.I. Marcus, and S.J. Cieciura. The HeLa S3 clone has been very useful in the clonal analysis of mammalian cell populations relating to chromosomal variation.

  • Description
    HeLa S3 is a subline of original HeLa cervical adenocarcinoma cell line, first established in 1951 from the cervical tumor of a 31-year-old African American female patient. This subline has been adapted for suspension culture while displaying an epithelial-like morphology. The karyotype is highly aneuploid, with a modal chromosome number of 68. HeLa S3 retains the tumorigenic potential of its parental line. HeLa S3 cells contain integrated sequences of human papilloma virus 18 (HPV-18), with multiple proviral insertions throughout the genome. They are frequently utilized in research focusing on chromosomal abnormalities, cell cycle regulation, and cytotoxicity. Their adaptability to suspension culture makes them especially suitable for large-scale biochemical and pharmaceutical assays.
  • Product Name
    HeLa S3
  • Product Type
    Human Uterine Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Cervix
  • Disease
    Cervical Cancer
  • Product Type
    Human Uterine Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    HELA S3 cells are extensively used in a variety of research areas, including cytogenetics, virology, and oncology. They serve as a robust model for studying chromosomal variation, nutritional requirements of mammalian cells, and clonal growth behavior. Their utility in plaque-forming assays and viral replication studies has also contributed significantly to the advancement of cell biology and genetic research. The HeLa S3 subline’s suspension-culture adaptability and genetic stability make it a preferred choice for high-throughput drug screening and cellular response analyses, particularly in evaluating cytotoxicity and genetic expression in human cancer cells.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    SMEM + 2mM Glutamine + 1% Non Essential Amino Acids +10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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