Free delivery over $100 Learn more

30 days return period Learn more
SKU: 0723ATC

Hep-G2 Human Epithelial Cells

Tumor Cell Lines > Liver Cancer Cell Lines

Product Type: Human Liver Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Other

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: Hep-G2

The cells express 3-hydroxy-3-methylglutaryl-CoA reductase and hepatic triglyceride lipase activities. The cells demonstrate decreased expression of apoA-I mRNA and increased expression of catalase mRNA in response to gramoxone (oxidative stress).

  • Description
    Hep-G2 is a human hepatoblastoma cell line derived from the liver tumor of a 15-year-old Caucasian male patient. These epithelial-like cells exhibit adherent growth properties and have a doubling time ranging from 48-72 hours under standard DMEM culture conditions. The karyotype is hyperdiploid, with a modal chromosome number of 55 and structural abnormalities including chromosome 1/21 translocations. Hep-G2 retains hepatocyte-specific functions, such as the expression of albumin, alpha-fetoprotein, and key hepatic metabolic enzymes like 3-hydroxy-3-methylglutaryl-CoA reductase. The cell line shows a TERT promoter mutation (C228T) commonly found in hepatocellular carcinomas. in contrast to its HBV-expressing subclone Hep-G2/2.2.15, the parental Hep-G2 line demonstrates low tumorigenicity in immunocompromised mice.
  • Product Name
    Hep-G2
  • Product Type
    Human Liver Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Product Type
    Human Liver Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Hep-G2 cell line, is widely utilized in pharmacological, toxicological, and liver function research, particularly for studies related to xenobiotic metabolism and drug elimination. Despite certain enzymatic limitations compared to primary hepatocytes, Hep-G2 cells remains a promise model in drug metabolism investigations and hepatotoxicity assessments, owing to its expression of drug metabolizing-enzymes and transport proteins relevant to both hepatocellular carcinoma and hepatoblastoma. Recent research efforts focused on amplifying the cytochrome P450 expression within Hep-G2 cells to enhance their utility as a hepatocyte model. Furthermore, 3D spheroid culture systems are being actively explored to establish a more physiologically relevant model, as these models demonstrate greater metabolic activity compared to conventional 2D cell cultures.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you