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SKU: 0077ATC

HL-60 Human Peripheral Blood Leukemia Myeloblast Cell Line

Tumor Cell Lines > Leukemia Cell Lines

Product Type: Human Leukemia Cell Lines

Species: Human

Cell Type: Myeloblast

Source Organ: Blood

$1,249.00
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Cell Name: HL-60

HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia.

  • Description
    HL-60 is a human promyeloblast cell line originally isolated from the peripheral blood of a 36-year-old Caucasian female diagnosed with acute promyelocytic leukemia (APL). HL-60 exhibits lymphoblast-like morphology and grow in suspension. HL-60 has a near-triploid karyotype, typically ranging from 64 to 78 chromosomes. This cell line expresses key myeloid differentiation markers such as CD33 and CD11b but lacks the PML-RARA fusion protein that is commonly present in classical APL cell. HL-60 is tumorigenic in SCID mice, where it can form granulocytic sarcomas following subcutaneous injection. HL-60 possess the capacity to differentiate into granulocyte- or monocyte-like lineages in response to chemical inducers such as retinoic acid (ATRA) or dimethyl sulfoxide (DMSO).
  • Product Name
    HL-60
  • Product Type
    Human Leukemia Cell Lines
  • Species
    Human
  • Cell Type
    Myeloblastic
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Promyelocytic Leukemia
  • Product Type
    Human Leukemia Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    HL-60 cells are a widely used model in hematological and cancer research. They are instrumental in studying leukemic cell proliferation, differentiation, apoptosis, and the mechanisms of myeloid lineage commitment. Their responsiveness to various differentiation agents makes them an ideal platform for evaluating the efficacy of anticancer drugs and chemotherapy efficiency. Additionally, HL-60 cells are valuable for investigating phagocytosis, calcium signaling, and the production of extracelluler vesicles (EV). Furthermore, HL-60 cells serve as an essential model system for immunological research and vaccine development, serving as a versatile in vitro system for elucidating cellular and molecular pathways in myeloid biology.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    IMDM + 20% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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