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SKU: 391BIC

Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

  • Description
    Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are isolated from the peripheral blood of patients with relapsed/refractory acute lymphoblastic leukemia (ALL).These cells are primary and typically used at early passages to preserve disease-specific characteristics. They appear as large round cells with high nuclear-to-cytoplasmic ratios and grow in suspension.These cells proliferate indefinitely by abnormally activating signaling pathways such as BCR-ABL1 and JAK-STAT, while escaping immune surveillance by downregulating.They frequently express CD10, CD19, and CD34, confirmed by flow cytometry.These cells are tumorigenic and have been shown to engraft and propagate in immunodeficient mouse models.MHC-I molecules and upregulating PD-L1, and secreting angiogenic factors (such as VEGF) and matrix remodeling proteins (such as MMP-9) to reconstruct the microenvironment
  • Product Name
    Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Lymphoid Leukemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) can be used to study the cellular and molecular mechanisms associated with Acute Lymphoid Leukemia. By studying related signaling pathways, it can help further explore the potential therapeutic strategies. In addition, they can also be used for drug development and screening.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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