Free delivery over $100 Learn more

30 days return period Learn more
SKU: 390BIC

Human Acute Myeloid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: Human Acute Myeloid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

  • Description
    Human Acute Myeloid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are derived from the peripheral blood of patients with relapsed/refractory acute myeloid leukemia (AML). They are peripheral blood mononuclear cells primarily composed of leukemic myeloblasts.These cells achieve unlimited proliferation by abnormally activating signaling pathways such as RTK-RAS-MAPK and WNT/β-catenin, and inhibit the expression of myeloid differentiation genes through epigenetic remodeling (such as DNMT3A mutation) to maintain the original state . These cells frequently exhibit complex karyotypic abnormalities, including monosomy 7, trisomy 8, or translocations such as t(8;21).They often express CD33, CD34, and CD117, confirmed via flow cytometry.At the same time, they highly express CD47 and secrete immunosuppressive factors such as IL-6/TGF-β, which can inhibit macrophage phagocytosis and induce T cell exhaustion, and cooperate with stromal cells (MSCs) in the bone marrow microenvironment to build an immune escape niche.
  • Product Name
    Human Acute Myeloid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Myeloid Leukemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Acute Myeloid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) can serve as an in vitro cell model to study AML pathogenesis and develop novel therapies. They can also be used to study constitutive activation of survival pathways (RTK-RAS, WNT/β-catenin), chemoresistance mechanisms (ABC transporter upregulation), and metabolic adaptations (OXPHOS dependency).
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you