SKU: 350BIC

Human Atopic Dermatitis Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

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Cell Name: Human Atopic Dermatitis Peripheral Blood Mononuclear Cells

  • Description
    Human Atopic Dermatitis Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with atopic dermatitis (AD), a chronic inflammatory skin disorder. These cells primarily consist of lymphocytes (T cells, B cells, and NK cells) and monocytes, which are key components in the immune response. AD-PBMCs are functionally implicated in the dysregulated immune response characteristic of AD, particularly through Th2-skewed cytokine production (e.g., IL-4, IL-5, IL-13) and IgE-mediated hypersensitivity. They also exhibit abnormal T-cell activation and altered function of monocyte-derived dendritic cells, contributing to skin barrier impairment and chronic inflammation.
  • Product Name
    Human Atopic Dermatitis Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Atopic Dermatitis
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Atopic Dermatitis Peripheral Blood Mononuclear Cells can be used to explore the molecular mechanisms underlying Th2-biased immune responses, skin barrier dysfunction and chronic inflammation. They are also suitable for in vitro experiments, such as cell culture, cytokine detection (such as IL-4, IL-5, IL-13 and IL-31), and flow cytometry analysis of changes in immune cell subsets to reveal the immune dysregulation characteristics of AD.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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