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SKU: 388BIC

Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

  • Description
    Human Chronic Lymphocytic Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of newly diagnosed and untreated chronic lymphocytic leukemia (CLL) patients.Common cytogenetic abnormalities include deletion 13q, trisomy 12, deletion 11q, and deletion 17p, detectable by FISH or karyotyping. Morphologically, these cells are mainly mature small lymphocyte-like, with small and round cell bodies. These cells typically express high levels of CD19, CD20 (dim), CD5, and CD23, detectable via flow cytometry.They are tumorigenic and may proliferate in immunodeficient mouse models under specific microenvironmental conditions.Their functional abnormalities are mainly manifested in the continuous activation of the B cell receptor (BCR) signaling pathway, which promotes cell survival; high expression of anti-apoptotic proteins (such as BCL-2 family members), which inhibit programmed cell death; at the same time, abnormal expression of cell adhesion molecules and chemokine receptors, which affects cell homing and tissue infiltration.
  • Product Name
    Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Chronic Lymphoid Leukemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Chronic Lymphocytic Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are ideal models for exploring the pathogenesis of CLL. They can be used to study key biological characteristics such as abnormal activation of B cell receptor (BCR) signaling pathways (such as BTK, PI3Kδ-dependent pathways), anti-apoptosis mechanisms (overexpression of the BCL-2 family), and epigenetic changes (such as abnormal miRNA regulation)
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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