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SKU: 387BIC

Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

  • Description
    Human Chronic Lymphocytic Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are derived from the peripheral blood of patients with relapsed or refractory chronic lymphocytic leukemia (CLL).Morphologically, the cells are mostly typical small lymphocyte-like, with small and round cell bodies, round or slightly irregular nuclei, and highly condensed chromatin. Relapsed/refractory CLL cells often exhibit cytogenetic abnormalities such as del(17p), del(11q), or trisomy 12, detectable by FISH or conventional karyotyping.When cultured in vitro, the cells grow in suspension. They commonly express CD19, CD5, CD23, and show aberrant expression of BCL2 and resistance-associated markers such as TP53 mutations. Detection is typically done using flow cytometry and PCR sequencing.These cells are directly related to relapsed/refractory CLL, and their clonal proliferation and abnormal survival lead to disease progression. Patients often experience symptoms such as anemia, infection, increased risk of bleeding, and organ involvement.
  • Product Name
    Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Chronic Lymphoid Leukemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Chronic Lymphocytic Leukemia Peripheral Blood Mononuclear Cells (Relapsed/Refractory) provide an ideal model for exploring the mechanism of chronic lymphocytic leukemia (CLL) resistance: acquired mutations (such as BTK C481S and PLCG2 mutations) can be analyzed through genome sequencing, and BCR signaling pathway reconstruction (such as reduced microenvironment dependence caused by CXCR4 downregulation) can be studied
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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