SKU: 1401APC

Human Colorectal Tumor Carcinoma Associated Fibroblasts Colorectal Cancer

Primary Cells > Intestine & Gastrointestinal Cells

Product Type: Human Primary Carcinoma Associated Fibroblasts

Species: Human

Cell Type: Fibroblasts

Source Organ: Intestine

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Cell Name: Human Colorectal Tumor Carcinoma Associated Fibroblasts

  • Description
    Human Colorectal Tumor Carcinoma Associated Fibroblasts (CAFs) are primary cells isolated from human colon tumor tissues. These cells exhibit spindle-shaped morphology and adherent culture properties. Functionally, they actively remodel the extracellular matrix (ECM) and secrete factors like HGF and IL-6, influencing tumor growth, angiogenesis, and chemoresistance. Markers like α-SMA, FAP, and vimentin are commonly used for characterization. This CAF model provides a physiologically relevant tool for studying tumor-stroma interactions.
  • Product Name
    Human Colorectal Tumor Carcinoma Associated Fibroblasts
  • Product Type
    Human Primary Carcinoma Associated Fibroblasts
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Colorectal
  • Disease
    Colorectal Tumor Carcinoma
  • Product Type
    Human Primary Carcinoma Associated Fibroblasts
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Leveraging our Human Colorectal Tumor Carcinoma Associated Fibroblasts (CAFs), researchers established a 3D interpenetrating network hydrogel culture system. This innovative platform facilitated modulation of the tumor microenvironment’s mechanical attributes, enabling an in-depth exploration of CAF phenotype transitions and interactions with colorectal cancer cells. Manipulating mechanical properties revealed conditions correlating with patient survival or decline, offering novel insights with potential implications for future cancer therapies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Colorectal Tumor Carcinoma Associated Fibroblasts Medium Kit
  • Shipping Conditions
    Dry ice
  • Storage
    Liquid Nitrogen

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