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Human Crohn’ s Disease Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Crohn’ s Disease Peripheral Blood Mononuclear Cells

  • Description
    Human Crohn’s Disease Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with Crohn’s Disease (CD). PBMCs, including lymphocytes (T cells, B cells, NK cells) and monocytes.Lymphocytes (T cells, B cells, NK cells) and monocytes are enriched from whole blood by density gradient centrifugation (such as Ficoll separation medium). Abnormally activated immune cell subsets may exist in PBMCs of patients with Crohn’s disease, such as changes in the proportion of CD4+ memory T cells or upregulated expression of monocyte chemokine receptors. Some subsets may exhibit upregulation of chemokine receptors (e.g., CCR2 on monocytes), activation markers (e.g., CD69, HLA-DR on T cells), or transcription factors (e.g., RORγt in Th17 cells), assessed by flow cytometry or qPCR.These cells are involved in abnormal immune responses, including overactivation of Th1/Th17 cells, defective regulatory T cell (Treg) function, and abnormal differentiation of monocytes into macrophages, leading to intestinal mucosal barrier destruction and chronic inflammation.
  • Product Name
    Human Crohn’ s Disease Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Crohn’ s Disease
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Crohn’s Disease Peripheral Blood Mononuclear Cells can be used to study the immune-driven mechanism of intestinal mucosal barrier destruction and chronic inflammation, and provide a theoretical basis for disease classification and targeted intervention. These cells can also be used for high-throughput drug screening and efficacy evaluation.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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