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Human Cystic Fibrosis Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Cystic Fibrosis Peripheral Blood Mononuclear Cells

  • Description
    Human Cystic Fibrosis Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of patients with cystic fibrosis (CF), mainly including lymphocytes, monocytes and dendritic cells. Morphologically, PBMCs are round or oval. PBMCs from CF patients play a key role in immune regulation and inflammatory response. Due to the mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the chloride channel function is defective, which causes abnormal extracellular environment and thus affects the function of PBMCs. These cells show excessive inflammatory response, such as increased secretion of proinflammatory cytokines (TNF-α, IL-6, IL-8), and increased oxidative stress levels, which aggravate chronic lung infection and tissue damage.
  • Product Name
    Human Cystic Fibrosis Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Cystic Fibrosis
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Cystic Fibrosis Peripheral Blood Mononuclear Cells can be used to explore the effects of CFTR gene mutations on immune cell function, including pathological processes such as abnormal secretion of inflammatory factors, enhanced oxidative stress, and autophagy disorders. These cells provide a valuable model for studying systemic immune disorders in cystic fibrosis.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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