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SKU: 383BIC

Human Diffuse Large B-Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Diffuse Large B-Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

  • Description
    Human Diffuse Large B-Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of patients with newly diagnosed but untreated diffuse large B-cell lymphoma (DLBCL). Tumor B cells often harbor chromosomal abnormalities including translocations involving BCL6, MYC, or BCL2 detected by cytogenetic or FISH analysis.They are enriched by density gradient centrifugation, often accompanied by co-isolation of tumor B cells and reactive immune cells (T cells, NK cells, monocytes). High expression of B cell markers CD19, CD20; activated B-cell markers MUM1; germinal center markers BCL6; and proliferation markers such as Ki-67.Morphologically, these cells are highly heterogeneous. They carry rearranged immunoglobulin genes (IGH/IGK/IGL), highly express activated B cells or germinal center B cell subtype characteristic molecules (such as MUM1, BCL6), continue to proliferate through pathways such as NF-κB, PI3K/AKT, and secrete factors such as IL-10 and CXCL13 to reshape the immune microenvironment.
  • Product Name
    Human Diffuse Large B-Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Diffuse Large B-Cell Lymphoma
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Diffuse Large B-Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) provides an important tool for analyzing DLBCL tumor heterogeneity, immune escape mechanisms, and resistance to targeted therapies (such as BTK inhibitors, PD-1/PD-L1 blockers), especially for longitudinal cohort analysis of newly diagnosed patient samples.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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