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Human Esophageal Epithelial Cells

Primary Cells > Intestine & Gastrointestinal Cells

Product Type: Esophageal Cells

Species: Human

Cell Type: Epithelial Cells

Source Organ: Esophagus

$1,249.00
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Cell Name: Human Esophageal Epithelial Cells

  • Description
    Human esophageal epithelial cells are Human Esophageal Epithelial Cells are derived from the human esophagus, a tubular organ made of mucosa, submucosa, muscle, and adventitia. These stratified squamous epithelial cells form a critical barrier against mechanical and chemical damage. The epithelium has three layers: a proliferating basal cell compartment (expressing CK5 and CK14), a differentiating suprabasal compartment (expressing CK4 and CK17), and a superficial squamous layer (containing filaggrin and involucrin). Unlike murine epithelium, human esophageal epithelium is non-keratinized and retains nuclei, providing a unique barrier function. These cells are used to study esophageal function, disease models (e.g., esophageal cancer, acid reflux, Barrett’s esophagus), and cellular responses to stress. Cryopreserved at early passages to maintain differentiation capacity, they should avoid repeated freeze-thaw cycles.
  • Product Name
    Human Esophageal Epithelial Cells
  • Product Type
    Esophageal Cells
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Esophagus
  • Disease
    Normal
  • Product Type
    Esophageal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human esophageal epithelial cells can be used to investigate gene expression involved in the formation of adherens and tight junctions and tight junctions. Using human esophageal epithelial cells, it was found that the loss of E-cadherin enhanced migration and invasion.. Moreover, EGFR overexpression induces epithelial hyperplasia and thickens epithelium. The expansion of the proliferating basal cells and impaired differentiation can be observed with the expression of inducible AKT in human esophageal epithelial cells. Otherwise, Esophageal squamous cell carcinoma (ESCC) is one of the most common and serious malignancies. Esophageal epithelial cell lines were used to identified potential biomarkers for ESCC, such as p53, Orai1, GPX3, REPS2, esophagin, proliferating cell nuclear antigen (PCNA), epithelial cell transforming sequence 2 (ECT2), etc.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Esophageal Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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