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SKU: 1264APC

Human Fetal Chondrocytes Cartilage

Primary Cells > Musculoskeletal Cells

Product Type: Cartilage Cells

Species: Human

Cell Type: Chondrocytes

Source Organ: Cartilage

$1,249.00
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Cell Name: Human Fetal Chondrocytes

  • Description
    Human Fetal Chondrocytes are primary cells isolated from normal articular cartilage of healthy human fetuses. As primary cells, they exhibit limited proliferation capacity and are not suitable for long-term passaging. These cells play a key role in cartilage development and are widely applied in disease modeling. In monolayer culture, they undergo de-differentiation into a fibroblast-like phenotype, which can be reversed in semi-solid gels. Their clonal growth is strongly stimulated by IGF-I and IGF-II, but not by insulin or growth hormone. They highly express COL2A1 and SOX9, confirmed by RT-PCR and immunostaining. HLA class I is expressed, while HLA class II remains low. Karyotyping shows normal chromosomal profiles. They exhibit low tumorigenicity and require high-glucose DMEM with 1% FBS under 37°C and 5% CO₂. These features make them a valuable model for studying cartilage regeneration and analyzing chondrogenic signaling pathways.
  • Product Name
    Human Fetal Chondrocytes
  • Product Type
    Cartilage Cells
  • Species
    Human
  • Cell Type
    Chondrocyte
  • Source Organ
    Cartilage
  • Disease
    Normal
  • Product Type
    Cartilage Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Fetal Chondrocytes are widely used in vitro to study cellular mechanisms, including inflammation-related signaling cascades, abnormal proteinase production, chondrocyte apoptosis, differentiation, and potential treatments for arthritic disease. They are essential for investigating[NEW LINE][NEW LINE][NEW LINE] the production and maintenance of the extracellular matrix, cartilage, and collagen, as well as signal transduction, apoptosis, differentiation, drug screening, gene expression, cytokine production, agarose assays, chondrocyte adhesion to medical implants, and scaffold design in cartilage regeneration.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Chondrocytes, Foetal Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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