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SKU: 1047APC

Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult Synovium

Primary Cells > Musculoskeletal Cells

Product Type: Synoviocytes

Species: Human

Cell Type: Fibroblasts

Source Organ: Joint (Synovium)

$1,249.00
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Cell Name: Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

  • Description
    Human Fibroblast-Like Synoviocytes Osteoarthritis, Adult (FLS-OA) are primary cells isolated from human synovial tissues. These cells typically cryopreserved at the earliest passage and have a proliferative capacity of ≥5 population doublings. FLS-OA constitute 75-80% of the synovial intimal lining and are classified as type B synoviocytes. Functionally, they play a critical role in maintaining joint homeostasis by contributing to synovial fluid formation and regulating chondrocyte nourishment. Under pathological conditions such as rheumatoid arthritis and osteoarthritis, they adopt an aggressive phenotype, characterized by increased secretion of pro-inflammatory cytokines and matrix metalloproteinases that contribute to cartilage degradation. These cells express characteristic markers, including Cadherin-11, VCAM-1, CD90 and CD55.
  • Product Name
    Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult
  • Product Type
    Synoviocytes
  • Species
    Human
  • Cell Type
    Fibroblast-Like
  • Source Organ
    synovium
  • Disease
    Normal
  • Product Type
    Synoviocytes
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Fibroblast-Like Synoviocytes Osteoarthritis (FLS-OA), serve as valuable tools in diverse research applications. They are essential in studying synoviocyte physiologyand understanding their role in the development and treatment of osteoarthritis. FLS cells are used to investigate various cellular processes, including phenotype profiling, proinflammatory mediator production, intracellular signaling pathways, cell proliferation, and chemotaxis. Moreover, when combined with normal FLS and rheumatoid arthritis-FLS, they facilitate studies on interleukin production, screening of potential anti-inflammatory and antirheumatic compounds, as well as assessing the production of erosive enzymes, providing critical insights into the complexities of osteoarthritis and potential therapeutic avenues.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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