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SKU: 1048APC

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult Synovium

Primary Cells > Musculoskeletal Cells

Product Type: Synoviocytes

Species: Human

Cell Type: Fibroblasts

Source Organ: Joint (Synovium)

$1,249.00
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Cell Name: Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

  • Description
    Human Fibroblast-Like Synoviocytes (HFLS) are primary cells derived from adult rheumatoid arthritis (RA) synovial tissue, identified as type B fibroblast-like synoviocytes, which are non-immune, spindle-shaped, and adherent. They are cryopreserved at the early passage. Unlike type A macrophage-like synoviocytes, HFLS synthesize extracellular matrix (ECM) and maintain joint structure under normal conditions. In RA, HFLS display pathogenic features like hyperproliferation, apoptosis resistance, and invasive behavior, secreting high levels of IL-6, IL-8, and MMPs to promote synovial hyperplasia and cartilage destruction. Cytogenetic analysis shows normal karyotype with no chromosomal abnormalities. They are widely used to study RA pathogenesis and anti-inflammatory drug screening. Characterization includes high vimentin and CD90 (Thy-1) expression.
  • Product Name
    Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
  • Product Type
    Synoviocytes
  • Species
    Human
  • Cell Type
    Fibroblast-Like
  • Source Organ
    synovium
  • Disease
    Normal
  • Product Type
    Synoviocytes
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (HFLS-RA) serve as a useful tool for understanding the etiology and pathogenesis of RA. They can be used to establish cellular models to study key cytokine production that contributes to RA, explore the molecular signaling pathways implicated in the development of joint inflammation, or to evaluate anti-inflammatory compounds and identify potential drug targets.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult Medium Kit
  • Quality Control
    All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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