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SKU: 1063APC

Human Hepatic Stellate Cells

Primary Cells > Liver & Biliary Cells

Product Type: Hepatic Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Liver

$1,249.00
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Cell Name: Human Hepatic Stellate Cells

  • Description
    Human Hepatic Stellate Cells (HSCs) are primary mesenchymal cells isolated from adult human liver tissue, representing a key component of hepatic non-parenchymal cell population. These perisinusoidal cells are characterized by their quiescent state under physiological conditions, characterized by cytoplasmic lipid droplets rich in vitamin A — storing over 80% of the body’s retinoid reserves. These cells are cryopreserved at earliest passage, ensuring high viability and minimal phenotypic drift. HSCs play essential roles in maintaining extracellular matrix (ECM) homeostasis, regulating vitamin A metabolism, and modulating hepatic microcirculation through interactions with endothelial cells and hepatocytes. HHSCs express molecular markers including desmin, glial fibrillary acidic protein (GFAP), and collagen type I alpha 1 chain (COL1A1). Upon actvation, HHSCs upregulate α-smooth mucle actin (α-SMA) and connective tissue growth factor (CTGF), hallmark features of transdifferentiation associated with liver injury and fibrosis. Cryopreserved HHSCs demonstrate sensitivity to repeated freeze-thaw cycles and should be handled with care to maintain optimal functionally.
  • Product Name
    Human Hepatic Stellate Cells
  • Product Type
    Hepatic Cells
  • Species
    Human
  • Cell Type
    Stellate Cell
  • Source Organ
    Liver
  • Disease
    Normal
  • Product Type
    Hepatic Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Hepatic Stellate Cells (HHSC) are highly relevant for a broad range of in vitro applications, including hepatotoxicity assessment, drug screening, and metabolism profiling. Their unique physiological characteristic makes them invaluable for investigating liver function, hepatic microenvironment dynamics, and liver disease progression. Additionally, gaining a deeper understanding of the molecular mechanisms behind HHSC activation is critical for developing innovative therapeutic approaches in treating hepatic fibrosis, potentially reducing morbidity and mortality rates among patients suffering from chronic liver injuries.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Hepatic Stellate Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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