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SKU: 362BIC

Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells

  • Description
    Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells (PBMCs) are mainly derived from the peripheral blood of HCV-infected patients. HCV invades cells by binding to receptors such as CD81 and SR-BI on the surface of PBMCs through the envelope glycoprotein E1/E2, replicates at a low level in the cytoplasm, and forms a persistent infection reservoir. Mononuclear cells with round lymphocytes and monocytes; typically non-adherent, suspension growthHCV replication in PBMC can escape immune surveillance and lead to chronic inflammatory response. Chronic HCV infection can cause cirrhosis and hepatocellular carcinoma, and is associated with neurocognitive dysfunction, which may be related to the potential invasion of the virus on the central nervous system and PBMC-mediated immune activation. Persistent HCV infection reservoir in PBMCs; immune evasion through viral replication; associated with systemic effects like cirrhosis, hepatocellular carcinoma, and neurocognitive dysfunction through immune activation.
  • Product Name
    Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Hepatitis C Virus
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells can be used to study the molecular mechanisms of virus evasion of immune clearance and establishment of persistent infection. They can also be used to screen small molecule inhibitors or immunomodulators targeting virus-host interactions, providing an experimental platform for the development of new HCV vaccines and therapeutic strategies for clearing viral reservoirs.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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