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Human Hypothyroidism Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Hypothyroidism Peripheral Blood Mononuclear Cells

  • Description
    Human Hypothyroidism Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with hypothyroidism. They contain lymphocytes (T cells, B cells, NK cells) and monocytes. Typical mononuclear morphology—round lymphocytes and monocytes with kidney-shaped or lobed nuclei.PBMCs participate in immune regulation and inflammatory response, among which lymphocytes dominate adaptive immunity (such as antibody production and cytotoxicity), and monocytes can differentiate into macrophages or dendritic cells, participating in innate immunity and antigen presentation. Imbalanced secretion of proinflammatory cytokines IL-6, TNF-α; evidence of autoreactive T cell activation. When thyroid function is hypo, the immune function of PBMCs may be abnormal, manifested as an imbalance in the secretion of proinflammatory cytokines (such as IL-6 and TNF-α), or T cell-mediated thyroid tissue damage associated with autoimmune thyroiditis.Functional abnormalities linked to autoimmune thyroiditis and immune-mediated thyroid tissue damage.
  • Product Name
    Human Hypothyroidism Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Hypothyroidism
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Hypothyroidism Peripheral Blood Mononuclear Cells can be used as in vitro cell models to study the cellular and molecular mechanisms of autoimmune thyroiditis, which helps develop targeted therapeutic strategies. In addition, they can also be used for drug screening, such as testing the inhibitory effects of immunomodulatory drugs on inflammatory factors.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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