SKU: 1320APC

Human Keratinocytes, Adult Skin

Primary Cells > Skin Cells

Product Type: Keratinocyte

Species: Human

Cell Type: Epithelial Cells

Source Organ: Skin

$1,249.00

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Cell Name: Human Keratinocytes, Adult

Description

Keratinocytes are the major cells to Human Keratinocytes, Adult are primary cells derived from adult human epidermis, specifically from the basal layer of the skin. These cells play a critical role in forming the epidermal barrier and protecting against mechanical, chemical, and microbial damage. They are used in studies of skin disorders such as psoriasis, squamous cell carcinoma, and wound healing. Keratinocytes differentiate into basal, spinous, granular, and cornified layers and exhibit small, polygonal morphology with a high nuclear-cytoplasmic ratio, becoming flatter during differentiation. Cells are typically used at early passage to ensure high viability. Karyotype analysis shows a normal diploid chromosomal set in early passages. These cells express keratinocyte-specific markers, including KRT5, KRT14 (basal), and KRT1, KRT10, and involucrin.
Product Name

Human Keratinocytes, Adult
Product Type

Keratinocyte
Species

Human
Cell Type

Keratinocyte
Source Organ

Skin
Disease

Normal
Product Type

Keratinocyte
Growth Conditions

37 °C, 5% CO2
Application

Human keratinocytes are widely used in scientific applications.. In would healing and some pathogenic conditions, growth factors and cytokines like IL-1, TNF-α, TGF-α, TGF-β, and IFN-γ affect keratinocyte activation. Keratinocytes respond to signals from fibroblasts, such as TGF-β, by expressing K5 and K14, which leads to the restoration of their healthy basal phenotype. The differentiation of keratinocytes is mediated through the involvement of the mitogen-activated protein kinase (MAPK) pathway, which is influenced by factors such as epidermal growth factor (EGF), TNF, and calcium influx. Keratinocytes are also involved in the immune signaling pathway, as they express Toll-like receptors (TLRs) that respond to pathogen-associated molecular patterns (PAMPs). Toll-like receptors are expressed in human keratinocytes.TLR3, 4, 5 ligand stimulation can trigger an immune response in keratinocytes..
Size/Quantity

1 vial
Recommended Medium And Supplement

Human Keratinocytes, Adult Medium Kit
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

1

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Human Keratinocytes, Adult Skin

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Human Keratinocytes, Adult Skin

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