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SKU: 1045APC

Human Kidney Podocyte Cells

Primary Cells > Kidney & Urinary Cells

Product Type: Renal Cells

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Kidney

$1,249.00
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Cell Name: Human Kidney Podocyte Cells

  • Description
    Human Kidney Podocyte Cells are primary cells isolated from human kidney glomerular tissue, typically from healthy donors, and are used at low passage numbers (≤5) to preserve their functional phenotype. These epithelial-like cells are specialized components of the kidney filtration barrier, with interdigitating foot processes forming filtration slits that regulate plasma protein passage into the urinary space. Podocytes are adherent, polarized, and exhibit vesicular transport as part of their filtration function. They express key markers such as podocin, nephrin, WT1, and synaptopodin, confirmed via immunostaining and PCR. These cells are non-tumorigenic and non-metastatic. Podocytes play a crucial role in preventing proteinuria under normal conditions, but are sensitive to injury and are implicated in diseases like focal segmental glomerulosclerosis, minimal change disease, and diabetic nephropathy. Karyotype analysis shows a normal diploid set of chromosomes (46,XX or 46,XY), further supporting their genetic stability.
  • Product Name
    Human Kidney Podocyte Cells
  • Product Type
    Renal Cells
  • Species
    Human
  • Cell Type
    Podocyte
  • Source Organ
    Kidney
  • Disease
    Normal
  • Product Type
    Renal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Kidney Podocytes in culture offer a reliable in vitro system for studying glomerular pathophysiology. These cultured cells can be utilized in various applications such as toxicology studies to assess the potential toxicity of substances on kidney function. Additionally, they serve as a platform to study the metabolism of drugs and therapeutic targeting, support drug discovery for glomerular-related kidney diseases. Furthermore, human kidney podocytes in culture contribute to research and development efforts focused on understanding glomerular filtration mechanisms, providing insights into the functioning of the kidney and potential interventions for various renal disorders.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Kidney Podocyte Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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