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SKU: 381BIC

Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory)

  • Description
    Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are derived from peripheral blood samples of patients with relapsed/refractory mantle cell lymphoma (MCL). Morphological analysis shows that this cell population mainly consists of atypical small lymphocytes, and its immunophenotype displays typical MCL features: Cyclin D1 and CD5 are diffusely and positively expressed, while SOX-11 is positive in some cases. The combination of these three markers provides a crucial basis for diagnosis.Its core genetic feature is the t(11;14)(q13;q32) chromosomal translocation, which leads to abnormal overexpression of the cyclin D1 (CCND1) gene, thereby driving the cell cycle out of control.Additionally, these cells exhibit persistent abnormal activation of the B cell receptor (BCR) signaling pathway, significantly enhancing tumor B cell survival by continuously activating downstream pathways such as PI3K/AKT and MAPK.
  • Product Name
    Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Mantle Cell Lymphoma
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory) can be used for high-throughput screening and efficacy verification of targeted drugs (such as BTK inhibitors, PI3K inhibitors), as well as sensitivity assessment of new immunotherapies (CAR-T, dual antibodies). In addition, these cells can also be used for drug resistance mechanism research and biomarker discovery to predict treatment response or relapse, including TP53 mutations and epigenetic changes.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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