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Human MS Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Bone Marrow

$1,249.00
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Cell Name: Human MS Peripheral Blood Mononuclear Cells

  • Description
    Human Multiple Sclerosis (MS) Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of MS patients using density gradient centrifugation and mainly include T cells, B cells, NK cells, monocytes, and dendritic cells. These cells play a central role in MS pathogenesis by contributing to inflammation, antigen presentation, and immune dysregulation. MS PBMCs show altered subsets, such as increased CCR7+IL-6+ T cells and decreased T-bet^hiCD4+ T cells, along with mitochondrial dysfunction and oxidative stress. Th17 cells and γδ T cells secrete IL-17A, driving neuroinflammation and CNS infiltration. Additionally, MS PBMCs secrete high levels of proinflammatory cytokines like IFN-γ and IL-6, while monocytes release regulatory cytokines such as IL-10. These features contribute to disease progression and offer potential targets for therapeutic intervention and biomarker development. Fresh MS PBMCs are available upon request for research applications.
  • Product Name
    Human MS Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Bone Marrow
  • Disease
    Normal
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Multiple Sclerosis Peripheral Blood Mononuclear Cells are ideal for investigating the immunopathogenesis of MS and exploring immune cell subset dysfunction. These cells are commonly used in T cell polarization studies, cytokine profiling, and immune checkpoint analysis to assess the pro-inflammatory/anti-inflammatory balance in MS patients. Researchers utilize them to evaluate the function of Th1, Th17, Treg cells, and their interaction with monocytes or dendritic cells, mimicking the autoimmune environment. In addition, MS-PBMCs serve as an ex vivo model for testing immunomodulatory therapies or biologics targeting IL-17, IFN-γ, or TNF-α. Their clinical relevance also makes them suitable for biomarker discovery, genetic profiling, and drug screening to personalize MS treatment strategies.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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