Free delivery over $100 Learn more

30 days return period Learn more
SKU: 380BIC

Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

  • Description
    Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of newly diagnosed and untreated multiple myeloma patients. They are separated by gradient centrifugation technology (such as Ficoll density gradient method) to obtain a mixed cell population rich in lymphocytes (T/B cells, NK cells), monocytes and dendritic cells. Morphologically, the cells are round and mononuclear, grow in suspension, and have weak adhesion ability. Clonal B cells overexpress monoclonal immunoglobulins; increased myeloid-derived suppressor cells (MDSCs) markers; T cells show inhibited function via arginase 1 and IDO pathways.Functionally, they contain immune surveillance and regulatory components, but they are abnormal due to the disease state: B cells proliferate clonally and secrete monoclonal immunoglobulins, the proportion of myeloid-derived suppressor cells (MDSCs) increases, and T cell function is inhibited through pathways such as arginase 1 and IDO, promoting tumor immune escape.
  • Product Name
    Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Multiple Myeloma
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Multiple myeloma is a plasma cell malignancy characterized by monoclonal plasma cell infiltration in the bone marrow, elevated serum M protein and organ damage (such as bone disease, renal failure). These cells are important models for studying the pathogenesis, drug resistance and development of targeted therapies (such as proteasome inhibitors and immunomodulatory drugs) of multiple myeloma, and are particularly suitable for exploring the biological behavior of early diseases and screening targets for immunotherapy (such as CAR-T).
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you