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SKU: 379BIC

Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Relapsed/Refractory)

  • Description
    Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are derived from the peripheral blood of patients diagnosed with relapsed or refractory multiple myeloma, a highly aggressive plasma cell malignancy. Round or quasi-round suspended cells with weak adhesion; intracytoplasmic vacuolation and enlarged nucleoli. Cell morphology is characterized by suspended growth of round or quasi-round cells with weak wall adhesion. Typical MM cells show intracytoplasmic vacuolation and enlarged nucleoli. High abnormal monoclonal immunoglobulin expression; Cereblon mutations; overexpression of peptidyl prolyl isomerase A (PPIA) linked to drug resistance.This cell line highly expresses abnormal monoclonal immunoglobulins and has significant drug resistance characteristics, such as resistance to immunomodulators such as lenalidomide and pomalidomide and proteasome inhibitors. The resistance mechanism is related to Cereblon protein mutation and overexpression of peptidyl propionyl isomerase A (PPIA)
  • Product Name
    Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Relapsed/Refractory)
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Multiple Myeloma
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Multiple Myeloma Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are an important model for studying the interaction between tumor resistance mechanisms and the myeloma microenvironment. This cell can be used as an in vitro validation platform for: 1) exploring key targets of resistance (such as Cereblon mutations and PPIA overexpression); 2) evaluating the efficacy of new immunotherapies, including BCMA/CD19 bispecific CAR-T cells and GPRC5D targeting antibodies; 3) developing innovative treatment options such as bispecific antibodies. Its unique resistance characteristics and primary cell characteristics provide an irreplaceable experimental system for precision treatment research of multiple myeloma.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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