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SKU: 319BIC

Human non-Hodgkin lymphoma (DLBCL) Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human non-Hodgkin lymphoma (DLBCL) Peripheral Blood Mononuclear Cells

  • Description
    Human non-Hodgkin lymphoma (DLBCL) Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with diffuse large B-cell lymphoma (DLBCL). DLBCL is an aggressive subtype of non-Hodgkin’s lymphoma originating from the germinal center. Morphologically, DLBCL cells can present in a variety of forms, such as centroblastic type and immunoblastic type. Diffuse large B-cell lymphoma (DLBCL) is marked by impaired B – cell receptor (BCR) signaling and the abnormal activation of crucial survival pathways, such as NF-κB, PI3K/Akt/mTOR, and JAK/STAT. These dysregulated pathways fuel unchecked cellular proliferation, impede apoptosis, and facilitate metabolic reprogramming towards aerobic glycolysis, thereby fulfilling the substantial energy requirements of the rapidly proliferating tumor cells.
  • Product Name
    Human non-Hodgkin lymphoma (DLBCL) Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Non-Hodgkin lymphoma
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human non-Hodgkin lymphoma (DLBCL) Peripheral Blood Mononuclear Cells can be used to study the pathogenesis of diseases. For example, by isolating malignant B cells, it is possible to analyze driving events such as abnormal BCR signaling pathways (such as persistent activation of NF-κB), epigenetic modifications (such as BCL6 super-enhancer mutations), etc. These cells can also be used for biomarker development.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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