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SKU: 1195APC

Human Oral Keratinocytes

Primary Cells > Oral & Craniofacial Cells

Product Type: Oral Cells

Species: Human

Cell Type: Epithelial Cells

Source Organ: Oral Cavity

$1,249.00
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Cell Name: Human Oral Keratinocytes

  • Description
    Human Oral Keratinocytes (HOKs) are primary epithelial cells isolated from the oral mucosa of healthy donors. These cells exhibit an adherent growth and display epithelial-like morphology, typically appearing as irregularly shaped polygonal or flattened cells. As the predominant cell type in the oral epithelium, HOKs serve as the primary physical and immunological barrier against microbial invasion and chemical insults. Functionally, they participate in inflammatory responses by producing cytokines, which are crucial for maintaining mucosal immunity. HOKs express high levels of keratins (K5/K14 and K6/K16, K17) and E-cadherin. They demonstrate limited proliferative capacity in culture, typically undergoing 2-3 passages before entering senescence. These cells are highly sensitive to freeze-thaw cycles and should not be repeatedly cryopreserved.
  • Product Name
    Human Oral Keratinocytes
  • Product Type
    Oral Cells
  • Species
    Human
  • Cell Type
    Keratinocyte
  • Source Organ
    Oral
  • Disease
    Normal
  • Product Type
    Oral Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Oral Keratinocytes (HOKs) provide a versatile, serum-free culture model for research in oral mucosal physiology and disease mechanisms. They are particularly valuable for studying epithelial barrier integrity, wound healing, and host-pathogen interactions. Their innate cytokine production makes them valuable for investigating inflammatory responses to microbial biofilms or chemical irritants in conditions like periodontitis or oral mucositis. In tissue engineering, these cells serve as components for reconstructing stratified epithelium in 3D culture systems that mimic oral mucosa for transplantation studies. Cultured primary HOKs retain donor-specific characteristics, enabling personalized studies on genetic predispositions to oral disorders.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Oral Keratinocytes Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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