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SKU: 0936APC

Human Orbital Fibroblasts Orbital Tissue

Primary Cells > Eye Cells

Product Type: Orbital Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Eye

$1,249.00
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Cell Name: Human Orbital Fibroblasts

  • Description
    Human orbital fibroblasts are derived from human orbital connective tissue. Following the primary culture, these cells are cryopreserved. Orbital fibroblasts contribute to the structural maintenance of orbital tissue. Studies have shown that these cells are implicated in Graves’ ophthalmopathy (GO). In vitro, human orbital fibroblasts exhibit distinct responses to stimulation, including binding to endothelin and producing high levels of IL-6 upon treatment with IL-1β. These cells should be handled carefully to avoid repeated freezing and thawing during culture.
  • Product Name
    Human Orbital Fibroblasts
  • Product Type
    Orbital Cells
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Orbital Tissue
  • Disease
    Normal
  • Product Type
    Orbital Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human orbital fibroblasts are a vital model for investigating diseases related to the connective tissue of the orbit, such as Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy (TAO). These fibroblasts enable researchers to study the significant inflammation characteristic of these conditions, where tissues become infiltrated by activated T lymphocytes and mast cells, leading to the excessive accumulation of hyaluronan. Using human orbital fibroblasts allows the exploration of communication pathways between fibroblasts and immune cells, providing insights into the mechanisms driving inflammation and disease progression, which could inform potential therapeutic approaches.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Orbital Fibroblasts Medium Kit
  • Quality Control
    All cells test negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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