SKU: 112BIC

Human Osteoclast Precursor Cells

Blood and Immune Cells & Products > Bone Marrow Cells

Product Type: Blood Products

Species: Human

Cell Type: Osteoblasts & Osteoclasts

Source Organ: Bone Marrow

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Cell Name: Human Osteoclast Precursor Cells

  • Description
    Human Osteoclast Precursor Cells (OCPs) are primary cells derived from the monocyte/macrophage lineage of human peripheral blood, bone marrow, or umbilical cord blood. These cells are precursors to multinucleated osteoclasts and are implicated in bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, and multiple myeloma. Following isolation, they are cryopreserved and typically not passaged due to their limited proliferative capacity. OCPs exhibit monocyte-like morphology. Functionally, OCPs express surface markers including CD14, CD11b, CD115, and RANK, with CD16+ subsets showing heightened osteoclastogenic potential in inflammatory conditions. Their differentiation is RANKL-dependent, making them powerful models for studying bone metabolism disorders.
  • Product Name
    Human Osteoclast Precursor Cells
  • Product Type
    Blood Products
  • Species
    Human
  • Cell Type
    Osteoclast
  • Source Organ
    Bone Marrow
  • Disease
    Normal
  • Product Type
    Blood Products
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Osteoclast Precursor Cells find versatile applications, notably in high-throughput studies targeting osteoporosis, bone resorption, and related diseases. They offer insights into environmental impacts on osteoclast formation and pathogenic derivation, while also enabling exploration of regulators like chemokines and M-CSF influencing osteoclast precursor cell recruitment to bone. Enhanced comprehension of OCPs’ nature, heterogeneity, and recruitment pathways holds promise for targeted therapies addressing osteoclast-specific concerns.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Osteoclast Precursor Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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